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Impact of feed restriction, chloroquine and deoxynivalenol on viral haemorrhagic septicaemia virus IVb in fathead minnow Pimephales promelas Rafinesque
Journal of Fish Diseases ( IF 2.5 ) Pub Date : 2020-11-09 , DOI: 10.1111/jfd.13300
Juan‐Ting Liu 1 , John S. Lumsden 1
Affiliation  

Autophagy can markedly alter host response to infectious disease, and several studies have demonstrated that a restricted diet or deoxynivalenol modulates autophagy and reduces mortality of fish due to bacterial disease. The picture is less clear for viral diseases of fish. Duplicate tanks of fathead minnow, Pimephales promelas Rafinesque, were fed a replete diet (control), 100 µM chloroquine, 5 µM deoxynivalenol, 10% (fasted) or 40% of a replete diet (pair‐fed) for 2 weeks and then experimentally infected by intraperitoneal injection with 2 × 105 viral haemorrhagic septicaemia virus IVb. Survival from highest to lowest for the different treatments was as follows: deoxynivalenol (average 43.3%); control (40.0%); pair‐fed (35.0%); fasted (33.3%); and chloroquine (21.7%). No treatment significantly altered the survival rate of fathead minnow after VHSV IVb infection when compared to controls; however, the fish fed with chloroquine had significantly lower survival rate than the fish fed deoxynivalenol (p < .05).

中文翻译:

饲料限制,氯喹和脱氧雪腐烯酚对黑头呆fat病毒性出血性败血病病毒IVb的影响Pimephales promelas Rafinesque

自噬可以显着改变宿主对传染病的反应,一些研究表明,饮食限制或脱氧雪茄烯醇可调节自噬并降低由于细菌性疾病引起的鱼类死亡率。对于鱼类的病毒性疾病,图片还不太清楚。在重复的黑头min鱼(Pimephales promelas Rafinesque)的罐中喂饱(对照),100 µM氯喹,5 µM脱氧雪茄烯醇,10%(禁食)或40%的日常饮食(成对进食),持续2周,然后进行实验腹腔注射2×10 5感染病毒性出血性败血症病毒IVb。不同处理方法从最高到最低的存活率如下:脱氧雪腐酚(平均43.3%);控制(40.0%); 成对(35.0%); 禁食(33.3%); 和氯喹(21.7%)。与对照组相比,没有治疗能显着改变VHSV IVb感染后fat鱼的存活率;然而,饲喂氯喹的鱼的存活率明显低于饲喂脱氧雪腐烯醇的鱼(p  <.05)。
更新日期:2021-01-12
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