当前位置: X-MOL 学术Nano-Struct. Nano-Objects › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Boron nitride nanotubes decorated with magnetite nanoparticles for application as a multifunctional system in cancer treatment
Nano-Structures & Nano-Objects Pub Date : 2020-11-06 , DOI: 10.1016/j.nanoso.2020.100616
Daniele Amato Moreira Nazar , Wellington Marcos Silva , Ester Figueiredo de Oliveira , Edesia Martins Barros de Sousa

In this work, in addition to seeking to evaluate the potential of BNNT as a ceramic matrix for stabilizing magnetite nanoparticles, it was also investigated the performance of the nanocomposite BNNT-Fe3 O4 as a multifunctional system to be applied both by magnetohyperthermia and for controlled drug release. The materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (MET), electron energy loss spectroscopy (EELS), Fourier transform infrared spectroscopy (FTIR), vibrant sample magnetometry (VSM) and Mössbauer spectroscopy. The results indicated an effective interaction of BNNT with the nanoparticles of magnetite and maghemite, showing a superparamagnetic behavior of the nanocomposite. Measurements of AC magnetic-field-induced heating properties of the obtained nanocomposite showed the potential of the BNNT-Fe3O4 sample to reach a temperature within the appropriate range for tumor cell death. The drug release test in the presence of an external magnetic field shows that the material can be activated by an alternating magnetic field provoking the vibration of the magnetic particles and the quick release of large quantities of drugs only in the region of interest. Therefore, the results confirm the system consisting of BNNT decorated with nanoparticles of magnetite (BNNT-Fe3O4) presented a multifunctional and promising character for applications related to cancer therapy, by magnetohyperthermia and chemotherapy



中文翻译:

用磁铁矿纳米粒子装饰的氮化硼纳米管,在癌症治疗中用作多功能系统

在这项工作中,除了试图评估BNNT作为稳定磁铁矿纳米颗粒的陶瓷基质的潜力外,还研究了纳米复合材料BNNT-Fe 3的性能。 Ø4作为一种多功能系统,可同时用于磁热疗和控制药物释放。通过X射线衍射(XRD),扫描电子显微镜(SEM),透射电子显微镜(MET),电子能量损失光谱(EELS),傅里叶变换红外光谱(FTIR),充满活力的样品磁强(VSM)和莫斯鲍尔光谱学。结果表明BNNT与磁铁矿和磁赤铁矿的纳米粒子有效地相互作用,显示出纳米复合材料的超顺磁行为。交流磁场诱导的纳米复合材料加热性能的测量表明,BNNT-Fe 3 O 4具有潜力样品温度达到适合肿瘤细胞死亡的范围。在存在外部磁场的情况下进行的药物释放测试表明,该材料可以通过交变磁场激活,从而引起磁性颗粒的振动,并仅在目标区域内快速释放大量药物。因此,结果证实了由由磁铁矿纳米粒子(BNNT-Fe 3 O 4)装饰的BNNT组成的系统,在磁热疗和化学疗法方面,具有与癌症治疗相关的应用的多功能性和有希望的特征。

更新日期:2020-11-09
down
wechat
bug