Drug release systems co-encapusulated with ammonium bicarbonate (ABC) could facilitate drug release upon acidic or thermal stimulations to improve therapeutic effect. However, it is not easy to control drug release rate, owing to relative stable temperature and acidic condition in living body. Besides, the additional loaded ABC reduces drug loading capacity. Herein, a near-infrared light triggered rapid drug release system with high loading capacity was developed by loading ABC and doxorubicin into yolk-shell structured Au nanorods@mesoporous silica. Gas bubbles were generated from the thermolysis of ABC utilizing photothermal effect of Au nanorods to extrude drug molecules. The mesoporous silica shell was finally destroyed along with growing bubbles, resulting in burst drug release. The photothermal therapeutic effect of Au nanorods also contributed in tumor treatment. The excellent therapeutic effect was demonstrated in cancer cells and tumor-bearing mice, which provides a new reference to achieve controllable rapid drug release in cancer medicine.

与碳酸氢铵（ABC）共包封的药物释放系统可以促进药物在酸性或热刺激下的释放，以提高治疗效果。然而，由于生物体内相对稳定的温度和酸性条件，药物释放速率的控制并不容易。此外，额外加载的 ABC 降低了载药量。在此，通过将 ABC 和阿霉素负载到蛋黄壳结构的金纳米棒@介孔二氧化硅中，开发了一种具有高负载能力的近红外光触发快速药物释放系统。利用金纳米棒的光热效应挤出药物分子，ABC 的热解产生气泡。介孔二氧化硅壳最终随着气泡的增长而被破坏，导致药物释放。Au纳米棒的光热治疗作用也有助于肿瘤治疗。在癌细胞和荷瘤小鼠中均表现出优异的治疗效果，为在癌症医学中实现可控的快速药物释放提供了新的参考。