Abstract A N-halamine precursor monomer, (3-acrylamidopropyl) trimethylammonium chloride (APTMAC) was attached onto mesoporous silica. The hydrogel of chitosan and mesoporous silica-supported N-halamine precursors (MSSNPs) was prepared with γ-chloropropyl-triethoxysilane (CPTES) as the cross-linking agent. A porous three-dimensional microstructure of the siloxane aerogels with low density and high porosity was obtained through lyophilization. After chlorination, the aerogels showed potent bactericidal activities against 100% of S. aureus (7.44 log) and E. coli O157:H7 (7.02 log) within 30 min. Compared with traditional hemostatic materials (pledget and bandage), siloxane aerogels displayed good liquid retention rate and hemostatic properties. Erythrocytes and platelets showed good adhesion properties on the surface of the aerogels. The N-halamine-based aerogels showed good bactericidal and hemostatic properties, which have potential application for wound dressings.

中文翻译：

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具有杀菌特性的壳聚糖/介孔二氧化硅混合气凝胶作为止血材料

摘要 N-卤胺前体单体，（3-丙烯酰胺丙基）三甲基氯化铵（APTMAC）附着在介孔二氧化硅上。以γ-氯丙基-三乙氧基硅烷（CPTES）为交联剂制备壳聚糖和介孔二氧化硅负载的N-卤胺前体（MSSNPs）的水凝胶。通过冻干获得低密度、高孔隙率的硅氧烷气凝胶的多孔三维微观结构。氯化后，气凝胶在 30 分钟内对 100% 的金黄色葡萄球菌 (7.44 log) 和大肠杆菌 O157:H7 (7.02 log) 显示出有效的杀菌活性。与传统止血材料（质子和绷带）相比，硅氧烷气凝胶显示出良好的液体保留率和止血性能。红细胞和血小板在气凝胶表面显示出良好的粘附特性。