Abstract The field of nanoscience has blossomed over the last two decades and the importance of nanotechnology has increased in areas such as computing, sensors, biomedicine, and many other applications. In the present study, recent important advances in the functionalization of graphene with an emphasis on the physical properties upon tailored modification have been reviewed. It has been observed that functionalization cannot only stabilize graphene’s unique properties but also introduce some new properties. The functionalization of graphene can be done with different methods like covalent functionalization, non-covalent functionalization, and with the decoration of nanoparticles. In this study, we put forward functionalization of graphene by polymers with different methods such as by direct linking of polymeric chains to the graphene surface or by the controlled growth of the polymeric chains at graphene surface or by decorating with polymers. The exceptional in-plane properties of graphene that are more complete exfoliation of graphite towards single graphene sheets with excellent mechanical, thermal, electrical, and barrier properties. The biological applications for the treatment of deadly diseases like cancer by functionalized nano-graphene oxide (NGO) have reviewed in depth. The application of NGO for drug delivery for gene therapy treatment has also discussed in this review.

中文翻译：

---

先进的功能化纳米氧化石墨烯作为药物递送和抗癌治疗的生物医学制剂：综述

摘要 纳米科学领域在过去的 20 年里蓬勃发展，纳米技术在计算、传感器、生物医学和许多其他应用领域的重要性日益增加。在本研究中，回顾了石墨烯功能化的最新重要进展，重点是定制改性后的物理特性。已经观察到功能化不仅可以稳定石墨烯的独特性能，还可以引入一些新的性能。石墨烯的功能化可以通过不同的方法完成，如共价功能化、非共价功能化和纳米粒子的装饰。在这项研究中，我们提出了通过聚合物使用不同方法对石墨烯进行功能化，例如通过将聚合物链直接连接到石墨烯表面或通过聚合物链在石墨烯表面的受控生长或通过用聚合物装饰。石墨烯卓越的面内特性，使石墨更完全地剥离成具有优异机械、热、电和阻隔性能的单个石墨烯片。已经深入回顾了功能化纳米氧化石墨烯（NGO）在治疗癌症等致命疾病的生物学应用。本综述还讨论了非政府组织在基因治疗药物递送中的应用。石墨烯卓越的面内特性，使石墨更完全地剥离成具有优异机械、热、电和阻隔性能的单个石墨烯片。已经深入回顾了功能化纳米氧化石墨烯（NGO）在治疗癌症等致命疾病的生物学应用。本综述还讨论了非政府组织在基因治疗药物递送中的应用。石墨烯卓越的面内特性，使石墨更完全地剥离成具有优异机械、热、电和阻隔性能的单个石墨烯片。已经深入回顾了功能化纳米氧化石墨烯（NGO）在治疗癌症等致命疾病的生物学应用。本综述还讨论了非政府组织在基因治疗药物递送中的应用。