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Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
Current Opinion in Solid State & Materials Science ( IF 11.0 ) Pub Date : 2020-11-06 , DOI: 10.1016/j.cossms.2020.100874
Caroline Uhler 1 , G V Shivashankar 2, 3
Affiliation  

In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs.



中文翻译:

肺组织硬度、EMT 和冠状病毒致病性的机械基因组耦合

在此当前意见中,我们强调了组织材料特性的重要性,以及其中影响上皮-间充质转化的改变如何代表许多疾病的重要调节层,并可能在宿主中发挥关键作用病原体相互作用。鉴于当前的 SARS-CoV-2 大流行,我们在此强调肺组织随着衰老而硬化的可能作用,以及这如何通过基质硬度依赖性肺上皮-间质转化促进 SARS-CoV-2 复制的增加上皮细胞。这强调了在药物发现计划中整合组织材料特性的必要性。

更新日期:2020-12-01
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