Antibiotic loaded calcium sulfate (CS) beads are widely reported to be used as bone void fillers. Application of these beads has been found effective in the inhibition of bacterial infections and enhanced bone regeneration, though lacking the ability to enhance angiogenesis. Thus, realizing the importance of angiogenesis for complete bone regeneration, magnesium oxide nanoparticles (MgO Nps) of ≤50 nm and tigecycline (Tg) incorporated CS based nanocomposite (Tg-NC) (Tigecycline-Nanocomposite) beads were prepared. N, O-carboxymethyl chitosan solution was chosen as a binder in the preparation of CS-based beads for the enhanced stability. The prepared Tg-NC beads were characterized using SEM, EDS and FTIR. The Tg-NC beads were cytocompatible showing pro-angiogenic property. The sustained drug release for 10 days from Tg-NC beads was found to be very effective in the inhibition of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Also, Tg-NC beads effectively inhibited biofilms exhibited by Staphylococcus aureus. Thus prepared Tg-NC beads can be used as bone void fillers for inhibiting infections and promoting angiogenesis.

载有抗生素的硫酸钙（CS）珠被广泛报道用作骨空隙填充剂。尽管缺乏增强血管生成的能力，但已发现这些珠粒的应用可有效抑制细菌感染并增强骨再生。因此，意识到血管生成对于完全骨再生的重要性，制备了≤50nm的氧化镁纳米粒子（MgO Nps）和掺有CS基纳米复合材料（Tg-NC）（Tigecycline-Nanocomposite）的替加环素（Tg）。N，O在基于CS的珠粒的制备中，选择了-羧甲基壳聚糖溶液作为粘合剂，以提高稳定性。使用SEM，EDS和FTIR表征制备的Tg-NC珠。Tg-NC珠是细胞相容性的，显示促血管生成性质。发现从Tg-NC珠持续释放药物10天对抑制金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌（MRSA）非常有效。同样，Tg-NC珠有效抑制金黄色葡萄球菌表现出的生物膜。如此制备的Tg-NC珠可以用作骨空隙填充剂，以抑制感染并促进血管生成。