During the COVID-19 pandemic, research on “cytokine storms” has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.

中文翻译：

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癌症和 COVID-19 中的细胞因子风暴

在 COVID-19 大流行期间，“细胞因子风暴”的研究在传染病领域重新焕发活力，但它也与癌症研究特别相关。白细胞介素 6 (IL-6) 已成为对 SARS-CoV-2 免疫反应的关键组成部分，因此针对 COVID-19 的抗 IL-6 疗法的再利用现在是一项主要研究方向，有几个正在进行的临床试验。我们建立了一个框架来理解 IL-6 在癌症研究和 COVID-19 中的作用，并提出从癌症研究中吸取的经验教训如何影响 SARS-CoV-2 研究，反之亦然。