Amphiphilic derivatives of (±)-trans-1,2-diselenane-4,5-diol (DST^ox) decorated with long alkyl chains or aromatic substituents via ester linkages were applied as glutathione peroxidase (GPx)-like catalysts. The reduction of H₂O₂ with the diselenide catalysts was accelerated through a GPx-like catalytic cycle, in which the diselenide (Se–Se) bond was reduced to the diselenolate form ([Se^-,Se^-]) by coexisting dithiothreitol, and the generated highly active [Se^-,Se^-] subsequently reduced H₂O₂ to H₂O retrieving the original Se–Se form. In the lipid peroxidation of lecithin/cholesterol liposomes induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), on the other hand, the Se–Se form directly reduced lipid peroxide (LOOH) to the corresponding alcohol (LOH), inhibiting the radical chain reaction, to exert the antioxidative effect. Thus, the two GPx-like catalytic cycles can be switched depending on the peroxide substrates. Furthermore, hydrophilic compounds with no or short alkyl groups (C3) showed high antioxidative activities for the catalytic reduction of H₂O₂, while lipophilic compounds with long alkyl chains (C6-C14) or aromatic substituents were more effective antioxidants against lipid peroxidation. In addition, these compounds showed low cytotoxicity in cultured HeLa cells and exhibited sufficient anti-lipid peroxidative activities, suggesting their potentials as selenium-based antioxidative drugs.

(±)-反式-1,2-二硒烷-4,5-二醇（DST ^ox）的两亲衍生物用长烷基链或芳族取代基通过酯键装饰，用作谷胱甘肽过氧化物酶（GPx）样催化剂。二硒化物催化剂对 H ₂ O ₂的还原通过类 GPx 催化循环加速，其中二硒化物 (Se-Se) 键通过共存的二硫苏糖醇还原为二硒化物形式 ([Se ^- ,Se ^- ])，并且生成的高活性 [Se ^- ,Se ^- ] 随后将 H ₂ O ₂还原为 H ₂O 检索原始 Se-Se 形式。另一方面，在由 2,2'-偶氮双（2-脒基丙烷）二盐酸盐（AAPH）诱导的卵磷脂/胆固醇脂质体的脂质过氧化中，Se-Se 形式直接将脂质过氧化物（LOOH）还原为相应的醇（LOH） )，抑制自由基链反应，发挥抗氧化作用。因此，两个 GPx 类催化循环可以根据过氧化物底物进行切换。此外，不含烷基或短烷基 (C3) 的亲水化合物在催化还原 H ₂ O _{2 方面}表现出很高的抗氧化活性。，而具有长烷基链（C6-C14）或芳香族取代基的亲脂性化合物是更有效的抗脂质过氧化抗氧化剂。此外，这些化合物在培养的 HeLa 细胞中显示出低细胞毒性，并表现出足够的抗脂质过氧化活性，表明它们具有作为硒基抗氧化药物的潜力。