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Growth regulation of luminescent gold nanoparticles directed from amphiphilic block copolymers: highly-controlled nanoassemblies toward tailored in-vivo transport
Science China Chemistry ( IF 9.6 ) Pub Date : 2020-11-05 , DOI: 10.1007/s11426-020-9862-1
Liting Nong , Tingyao Zhou , Huarui Chen , Bing Tang , Jinbin Liu

The understanding of amphiphilic block copolymers (ABC) in encapsulation and transport of inorganic nanomedicines is highly desired. Still, it remains limited due to the challenges in the fabrication of nanoassemblies (NAs) with highly-controlled shape and loading of nanoparticles. Herein, through growth regulation of luminescent gold nanoparticles (AuNPs) by different reductants with ABC pluronic F127 as a template, a straightforward strategy is reported for in-situ fabrication of three well-controlled gold NAs (AuNAs) that display tunable shapes from spherical to elongated nanostructures and controllable surface chemistry and loading of AuNPs with distinct emissions but identical individual AuNP size. The three AuNAs exhibit tailored in-vivo transport behaviours: those with spherical shape and more hydrophilic surface show longer blood retention with higher tumor-targeting efficiency (∼25.3% injection dose/g) and excellent long-term near-infrared tumor imaging even after 96 h post-injection. These findings provide a useful guidance in designing specific nanostructures for future nanomedicine transport.



中文翻译:

两亲性嵌段共聚物指导的发光金纳米颗粒的生长调节:针对定制的体内转运的高度受控的纳米组件

高度希望了解无机纳米药物的包封和运输过程中的两亲性嵌段共聚物(ABC)。然而,由于在具有高度可控的形状和纳米粒子负载的纳米组件(NA)的制造中所面临的挑战,它仍然受到限制。本文中,通过以ABC普朗尼克F127为模板,通过不同还原剂对发光金纳米颗粒(AuNPs)的生长调节,报道了一种简单的策略,用于就地制备三个可控形状的金纳米晶(AuNA),这些金纳米晶显示从球形到球形的可调形状细长的纳米结构和可控的表面化学性质以及AuNP的负载,具有不同的发射,但单个AuNP尺寸相同。三个AuNA展示了量身定制的体内转运行为:球形和亲水性更强的表面表现出更长的血液滞留时间,具有更高的肿瘤靶向效率(约25.3%注射剂量/ g),甚至在注射后96 h仍具有出色的长期近红外肿瘤成像。这些发现为设计未来纳米药物运输的特定纳米结构提供了有用的指导。

更新日期:2020-11-09
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