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Forensic NMR metabolomics: one more arrow in the quiver
Metabolomics ( IF 3.6 ) Pub Date : 2020-11-07 , DOI: 10.1007/s11306-020-01743-6
Emanuela Locci 1, 2 , Giovanni Bazzano 1 , Alberto Chighine 1 , Francesco Locco 1 , Ernesto Ferraro 1 , Roberto Demontis 1 , Ernesto d'Aloja 1
Affiliation  

Introduction

NMR metabolomics is increasingly used in forensics, due to the possibility of investigating both endogenous metabolic profiles and exogenous molecules that may help to describe metabolic patterns and their modifications associated to specific conditions of forensic interest.

Objectives

The aim of this work was to review the recent literature and depict the information provided by NMR metabolomics. Attention has been devoted to the identification of peculiar metabolic signatures and specific ante-mortem and post-mortem profiles or biomarkers related to different conditions of forensic concern, such as the identification of biological traces, the estimation of the time since death, and the exposure to drugs of abuse.

Results and Conclusion

The results of the described studies highlight how forensics can benefit from NMR metabolomics by gaining additional information that may help to shed light in several forensic issues that still deserve to be further elucidated.



中文翻译:

法医NMR代谢组学:箭袋中的另一个箭头

介绍

由于有可能研究内源性代谢谱和外源性分子,这可能有助于描述代谢模式及其与法医目的特定条件相关的修饰,因此NMR代谢组学已越来越多地用于法医学。

目标

这项工作的目的是回顾最新文献并描述NMR代谢组学提供的信息。人们一直致力于识别与不同法医关注条件有关的特殊代谢特征以及特定的验前和验尸资料或生物标志物,例如生物痕迹的鉴定,死亡时间的估计以及暴露的暴露。滥用毒品。

结果与结论

所描述研究的结果突显了法医如何通过获取其他信息来从NMR代谢组学中受益,这些信息可能有助于阐明一些仍需进一步阐明的法医问题。

更新日期:2020-11-09
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