Data regarding the association between pemphigus and rheumatoid arthritis (RA) is inconclusive and yet to be firmly established. In the current study, we aimed to evaluate the risk of developing RA during the course of pemphigus. A large-scale population-based longitudinal cohort study was conducted to evaluate the hazard ratio (HR) of RA among 1985 patients with pemphigus relative to 9874 age-, sex-, and ethnicity-matched control subjects. A multivariate Cox regression model was utilized. The incidence of RA was 1.07 (95% CI, 0.62–1.72) and 0.36 (95% CI, 0.24–0.52) per 1000 person-years among patients with pemphigus and controls, respectively. The lifetime prevalence of RA was 2.3% (95% CI, 1.7–3.1%) among cases and 1.8% (95% CI, 1.5–2.0%) among controls. Patients with pemphigus were more than twice as likely to develop RA as compared to control subjects (adjusted HR, 2.54; 95% confidence interval [CI], 1.31–4.92). The increased risk was robust to a sensitivity analysis that included only cases managed by pemphigus-related systemic medications (adjusted HR, 2.56; 95% CI, 1.30–5.05). In conclusion, pemphigus is associated with an increased risk of RA. Physicians treating patients with pemphigus should be aware of this possible association. Further research is required to better understand the mechanism underlying this association.

关于天疱疮与类风湿性关节炎 (RA) 之间关联的数据尚无定论，尚未确定。在目前的研究中，我们旨在评估天疱疮过程中发生 RA 的风险。一项大规模基于人群的纵向队列研究旨在评估 1985 名天疱疮患者与 9874 名年龄、性别和种族匹配的对照受试者的 RA 风险比 (HR)。使用多元Cox回归模型。天疱疮患者和对照组的 RA 发生率分别为每 1000 人年 1.07（95% CI，0.62-1.72）和 0.36（95% CI，0.24-0.52）。RA 的终生患病率在病例中为 2.3%（95% CI，1.7-3.1%），在对照组中为 1.8%（95% CI，1.5-2.0%）。与对照组相比，天疱疮患者发生 RA 的可能性是对照组的两倍以上（调整后的 HR，2.54；95% 置信区间 [CI]，1.31-4.92）。增加的风险对敏感性分析是稳健的，该分析仅包括由天疱疮相关全身药物治疗的病例（调整后的 HR，2.56；95% CI，1.30-5.05）。总之，天疱疮与 RA 风险增加有关。治疗天疱疮患者的医生应该意识到这种可能的关联。需要进一步研究以更好地了解这种关联的潜在机制。天疱疮与 RA 风险增加有关。治疗天疱疮患者的医生应该意识到这种可能的关联。需要进一步研究以更好地了解这种关联的潜在机制。天疱疮与 RA 风险增加有关。治疗天疱疮患者的医生应该意识到这种可能的关联。需要进一步研究以更好地了解这种关联的潜在机制。