Pneumonia is a major cause of morbidity and mortality worldwide and causes a significant burden on the healthcare systems. Curcumin is a natural phytochemical with anti-inflammatory and anti-neoplastic characteristics. The aim of this study was to conduct a systematic review of published studies on the effect of curcumin on preclinical models of pneumonia. A comprehensive search was conducted in PubMed/Medline, Scopus, Web of Science and Google Scholar from inception up to March 1, 2020 to recognize experimental or clinical trials assessing the effects of curcumin on pneumonia. We identified 17 primary citations that evaluated the effects of curcumin on pneumonia. Ten (58.8%) studies evaluated the effect of curcumin on mouse models of pneumonia, generated by intranasal inoculation of viruses or bacteria. Seven (41.2%) studies evaluated the inhibitory effects of curcumin on the pneumonia-inducing bacteria. Our results demonstrated that curcumin ameliorated the pneumonia-induced lung injury, mainly through a reduction of the activity and infiltration of neutrophils and the inhibition of inflammatory response in mouse models. Curcumin ameliorates the severity of pneumonia through a reduction in neutrophil infiltration and by amelioration of the exaggerated immune response in preclinical pneumonia models.

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姜黄素对肺炎作用的评价：临床前研究的系统评价

肺炎是全球发病率和死亡率的主要原因，并给医疗保健系统造成重大负担。姜黄素是一种具有抗炎和抗肿瘤特性的天然植物化学物质。本研究的目的是对已发表的关于姜黄素对肺炎临床前模型影响的研究进行系统评价。从开始到 2020 年 3 月 1 日，在 PubMed/Medline、Scopus、Web of Science 和 Google Scholar 中进行了全面搜索，以识别评估姜黄素对肺炎影响的实验或临床试验。我们确定了 17 项评估姜黄素对肺炎影响的主要引文。十项 (58.8%) 研究评估了姜黄素对由鼻内接种病毒或细菌产生的肺炎小鼠模型的影响。七 (41. 2%) 研究评估了姜黄素对肺炎诱导细菌的抑制作用。我们的研究结果表明，姜黄素主要通过降低中性粒细胞的活性和浸润以及抑制小鼠模型的炎症反应来改善肺炎引起的肺损伤。姜黄素通过减少中性粒细胞浸润和改善临床前肺炎模型中夸大的免疫反应来改善肺炎的严重程度。