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Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies
Phytotherapy Research ( IF 4.087 ) Pub Date : 2020-11-05 , DOI: 10.1002/ptr.6939
Babak Alikiaii, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar

Pneumonia is a major cause of morbidity and mortality worldwide and causes a significant burden on the healthcare systems. Curcumin is a natural phytochemical with anti‐inflammatory and anti‐neoplastic characteristics. The aim of this study was to conduct a systematic review of published studies on the effect of curcumin on preclinical models of pneumonia. A comprehensive search was conducted in PubMed/Medline, Scopus, Web of Science and Google Scholar from inception up to March 1, 2020 to recognize experimental or clinical trials assessing the effects of curcumin on pneumonia. We identified 17 primary citations that evaluated the effects of curcumin on pneumonia. Ten (58.8%) studies evaluated the effect of curcumin on mouse models of pneumonia, generated by intranasal inoculation of viruses or bacteria. Seven (41.2%) studies evaluated the inhibitory effects of curcumin on the pneumonia‐inducing bacteria. Our results demonstrated that curcumin ameliorated the pneumonia‐induced lung injury, mainly through a reduction of the activity and infiltration of neutrophils and the inhibition of inflammatory response in mouse models. Curcumin ameliorates the severity of pneumonia through a reduction in neutrophil infiltration and by amelioration of the exaggerated immune response in preclinical pneumonia models.

中文翻译:

姜黄素对肺炎的疗效评估:临床前研究的系统评价

肺炎是全世界发病率和死亡率的主要原因,并给医疗保健系统造成巨大负担。姜黄素是具有抗炎和抗肿瘤特性的天然植物化学物质。这项研究的目的是对姜黄素对肺炎的临床前模型的影响的已发表研究进行系统的综述。从成立到2020年3月1日,我们在PubMed / Medline,Scopus,Web of Science和Google Scholar中进行了全面搜索,以识别评估姜黄素对肺炎影响的实验或临床试验。我们确定了17项主要引用文献,以评估姜黄素对肺炎的影响。十项(58.8%)研究评估了姜黄素对鼻内接种病毒或细菌产生的肺炎小鼠模型的影响。七(41。2%)研究评估了姜黄素对肺炎诱导细菌的抑制作用。我们的结果表明姜黄素主要通过减少中性粒细胞的活性和浸润以及抑制小鼠模型中的炎症反应来减轻肺炎引起的肺损伤。姜黄素通过减少中性粒细胞浸润和改善临床前肺炎模型中夸大的免疫反应来改善肺炎的严重程度。
更新日期:2020-11-05
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