Lower acute respiratory infections (ARI) are a frequent cause of morbidity and mortality in infants, respiratory viruses being the major causative agents. The aim of this work was to determine the respiratory pathogen frequency, the clinical characteristics and the outcome in infants <2 months old hospitalized with ARI. A retrospective study was performed during a five-year period (2008–2011, 2014–2016). Respiratory viruses and atypical bacteria were studied using the FilmArray-Respiratory Panel. Demographic and clinical characteristics, hospitalization course and outcomes were evaluated. Of the 137 infants <2 months old hospitalized with ARI studied, a 94.9% positivity rate as determined in 117 infants with community-acquired infection and 20.0% in 20 infants who acquired the infection during their birth hospitalization in the neonatal intensive care units (NICU) (nosocomial ARI) (p < 0.001). In infants with community-acquired infection, Respiratory syncytial virus (RSV) (52.1%) and Rhinovirus/Enterovirus (RV/EV) (41.0%) were the most frequent detected pathogens. Coinfections were determined in one quarter of the infants, RSV-RV/EV being the most frequent combination. In infants with nosocomial infection, RV/EV, RSV or Parainfluenza-3 were detected as single pathogens. Most infants with community-acquired infection presented lower ARI (81.2%) while most infants in the NICU had upper ARI (55.0%). The median length of stay (LOS) in infants with community-acquired ARI was 4 days (IQR: 2–6). Positive infants with nosocomial infection had longer median LOS (71 days [IQR:42–99]) compared to negative infants (58 days [IQR: 49–71]) (p = 0.507). Respiratory viruses were detected as the major causative agents of community-acquired infection in hospitalized infants <2-months old, RSV and RV/EV being the most frequently detected. Although a low pathogen positivity rate was observed in infants with nosocomial infection, they may prolong the LOS.

下急性呼吸道感染 (ARI) 是婴儿发病率和死亡率的常见原因，呼吸道病毒是主要病原体。这项工作的目的是确定因 ARI 住院的 <2 个月大婴儿的呼吸道病原体频率、临床特征和结果。在五年期间（2008-2011、2014-2016）进行了一项回顾性研究。使用 FilmArray-Respiratory Panel 研究呼吸道病毒和非典型细菌。评估了人口统计学和临床​​特征、住院过程和结果。在接受研究的 137 名 <2 个月大的 ARI 婴儿中，117 名社区获得性感染婴儿和 20 名婴儿的阳性率为 94.9%。p  <  0.001)。在社区获得性感染婴儿中，呼吸道合胞病毒(RSV) (52.1%) 和鼻病毒/肠道病毒(RV/EV) (41.0%) 是最常见的病原体。在四分之一的婴儿中确定了合并感染，RSV-RV/EV 是最常见的组合。在患有医院感染、RV/EV、RSV 或副流感-3 的婴儿中被检测为单一病原体。大多数社区获得性感染婴儿的 ARI 较低（81.2%），而 NICU 中的大多数婴儿的 ARI 较高（55.0%）。社区获得性 ARI 婴儿的中位住院时间 (LOS) 为 4 天（IQR：2-6）。与阴性婴儿（58 天 [IQR：49-71]）相比，患有医院感染的阳性婴儿的中位 LOS（71 天 [IQR：42-99]）更长（p  = 0.507  ）。呼吸道病毒被检测为 <2 个月大的住院婴儿社区获得性感染的主要病原体，其中 RSV 和 RV/EV 是最常检测到的。尽管在医院感染婴儿中观察到的病原体阳性率较低，但它们可能会延长 LOS。