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Commissioning and validation of TOPAS beam model for IBA Proteus-ONE at UFHPTI
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2021-03-01 , DOI: 10.1016/j.radphyschem.2020.109256
Chunbo Liu , Yawei Zhang , Zuofeng Li , Xiaoying Liang , Jiyeon Park , Yuntao Song , Hansheng Feng

Abstract Proteus-ONE (P-ONE) is a novel compact single-room system developed by Ion Beam Application (IBA, Belgium) for proton therapy. The objective of this research was to commission and validate Monte Carlo (MC) beam model for P-ONE using the TOol of PArticle Simulation (TOPAS) Monte Carlo software package. Thirty-three energies were determined within P-ONE energy range (70-227 MeV) to measure integral depth dose (IDD), absolute dose and in-air lateral profiles. The beam model was established by matching TOPAS simulation with measurement for each energy. To validate the accuracy of obtained TOPAS beam model, we compared TOPAS simulation with measurement under various scenarios, including different spread-out Bragg peaks, lateral dose curves and gamma passing rates (GPRs) for 3x3x3 cm3, 5x5x5 cm3, and 7x7x7 cm3 uniform target in a water phantom. Good agreement was observed and GPRs reached 100% among all measurement planes with 3%/3mm criteria and above 95% with 2%/2mm criteria. Three patient cases including head and neck, breast and prostate were used for gamma analysis and at least GPRs of 99.8% and 95.4% were reached among all measurement planes with the criteria of 3%/3mm and 2%/2m, respectively. The results indicated the accuracy and reliability of the obtained TOPAS beam model which has the potential to serve clinical or research purposes.

中文翻译:

在 UFHPTI 为 IBA Proteus-ONE 调试和验证 TOPAS 梁模型

摘要 Proteus-ONE(P-ONE)是由Ion Beam Application(IBA,比利时)开发的一种用于质子治疗的新型紧凑型单室系统。本研究的目的是使用粒子模拟工具 (TOPAS) 蒙特卡罗软件包委托和验证 P-ONE 的蒙特卡罗 (MC) 光束模型。在 P-ONE 能量范围 (70-227 MeV) 内确定了 33 种能量,以测量积分深度剂量 (IDD)、绝对剂量和空中横向分布。光束模型是通过将 TOPAS 模拟与每个能量的测量相匹配来建立的。为了验证获得的 TOPAS 光束模型的准确性,我们将 TOPAS 模拟与各种场景下的测量进行了比较,包括 3x3x3 cm3、5x5x5 cm3 和 7x7x7 cm3 均匀目标的不同展开布拉格峰、横向剂量曲线和伽马通过率 (GPR)在水幻象中。观察到良好的一致性,所有测量平面的 GPR 在 3%/3mm 标准下达到 100%,在 2%/2mm 标准下达到 95% 以上。对头颈部、乳腺、前列腺三个病例进行γ分析,所有测量平面的GPR至少达到99.8%和95.4%,标准分别为3%/3mm和2%/2m。结果表明所获得的 TOPAS 光束模型的准确性和可靠性,具有用于临床或研究目的的潜力。分别。结果表明所获得的 TOPAS 光束模型的准确性和可靠性,具有用于临床或研究目的的潜力。分别。结果表明所获得的 TOPAS 光束模型的准确性和可靠性,具有用于临床或研究目的的潜力。
更新日期:2021-03-01
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