Ovarian follicular development, which dependent on the proliferation and differentiation of granulosa cells (GCs), is a complex biological process in which miRNA plays an important role. Our previous study showed that miR-458b-5p is associated with ovarian follicular development in chicken. The detailed function and molecular mechanism of miR-458b-5p in GCs is unclear.

中文翻译：

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miR-458b-5p靶向CTNNB1，通过Wnt /β-catenin信号通路调节卵巢颗粒细胞的增殖。

卵巢卵泡发育取决于颗粒细胞（GCs）的增殖和分化，是一个复杂的生物学过程，其中miRNA起着重要的作用。我们以前的研究表明，miR-458b-5p与鸡卵巢卵泡发育有关。目前尚不清楚miR-458b-5p在GC中的详细功能和分子机理。