Background: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.
Methods and Materials: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding.
Results: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect.
Conclusion: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.



中文翻译：

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线粒体靶向氧充足的全氟化碳纳米颗粒用于成像引导的肿瘤光疗

背景：虽然光热疗法（PTT）和光动力疗法（PDT）在肿瘤治疗方面都取得了显着进展，但由于PTT穿透深度和肿瘤缺氧微环境的限制，单独使用PTT或PDT的效果并不理想。太平洋夏令时。联合光疗目前已成为一种新兴的癌症治疗方法。
方法和材料：在这项工作中，通过图像引导，开发了一种基于线粒体靶向液体全氟化碳 (PFC) 的氧气输送系统，用于癌症的协同 PDT/光热疗法 (PTT)。
结果：重要的是，这些纳米粒子 (NPs) 可以通过增强的渗透性和保留 (EPR) 效应有效且准确地积聚在目标肿瘤中。
结论：该方法提供了一种新颖的技术，通过一种前所未有的设计来实现出色的抗肿瘤功效，该设计具有肿瘤线粒体靶向、氧气输送和协同 PDT/PTT 以及双成像引导。