AIM To analyse the influence of the degree of conversion (DC) and light curing residues of different bulk fills (BFs) composites on the inflammatory profile in the subcutaneous tissue of rats. MATERIALS AND METHODS Resin disks of BF-resins and their active conventional resins (CR; 3M®, Ivoclar®, and Kerr®) were light-cured at 2 mm (BF-superficial) and 4 mm (BF-deep) thicknesses and analyzed by infrared spectroscopy (FTIR; n = 3/group; DC and light curing residues). Then, the disks were implanted in four quadrants in the subcutaneous tissue of Wistar rats (sham, CR, BF-superficial and RF-deep), and after 7, 14, and 28 days, the animals (n = 6/day) were euthanized for histological analysis of the intensity of the inflammatory process (scores 0-3). Kruskal-Wallis/Dunn and ANOVA/Bonferroni tests were used (p < 0.05, Graph Pad Prism 5.0). RESULTS The DC of CR 3M® did not differ significantly compared to BF-superficial and BF-deep resins (p = 0.235). The Ivoclar® and Kerr® resins showed a higher DC with CR and BF-superficial compared to the BF-deep (p = 0.005 and p = 0.011, rctively). Kerr® resins showed a higher Bis-GMA/UDMA ratio, especially in BF-deep resin (p < 0.05). 3M® and Ivoclar resins did not show high inflammation scores, but for Kerr® BF resins (superficial and deep), the inflammatory process was significantly higher than that in the CR and sham quadrants (p = 0.031). CONCLUSION The tissue inflammatory response after resin inoculation depends on the DC and light curing residues of Bis-GMA.

中文翻译：

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散装填充树脂的转化程度和 Bis-GMA 残留对大鼠皮下模型组织毒性的影响

目的分析不同散装填充物（BFs）复合材料的转化度（DC）和光固化残留物对大鼠皮下组织炎症谱的影响。材料和方法 BF 树脂及其活性常规树脂（CR；3M®、Ivoclar® 和 Kerr®）的树脂盘在 2 mm（BF-表面）和 4 mm（BF-深）厚度下进行光固化并进行分析通过红外光谱（FTIR；n = 3/组；DC 和光固化残留物）。然后，将椎间盘植入 Wistar 大鼠皮下组织的四个象限（假、CR、BF-浅表和 RF-深），并在 7、14 和 28 天后，动物（n = 6/天）安乐死以进行炎症过程强度的组织学分析（得分 0-3）。使用了 Kruskal-Wallis/Dunn 和 ANOVA/Bonferroni 检验（p < 0.05，Graph Pad Prism 5.0）。结果 CR 3M® 的 DC 与 BF 浅表树脂和 BF 深树脂相比没有显着差异 (p = 0.235)。与 BF-deep 相比，Ivoclar® 和 Kerr® 树脂在 CR 和 BF-表面显示出更高的 DC（p = 0.005 和 p = 0.011）。Kerr® 树脂表现出更高的 Bis-GMA/UDMA 比率，尤其是在 BF 深树脂中 (p < 0.05)。3M® 和 Ivoclar 树脂的炎症评分不高，但 Kerr® BF 树脂（浅表和深层）的炎症过程明显高于 CR 和假象限（p = 0.031）。结论树脂接种后的组织炎症反应取决于Bis-GMA的DC和光固化残留物。与 BF-deep 相比，Ivoclar® 和 Kerr® 树脂在 CR 和 BF-表面显示出更高的 DC（p = 0.005 和 p = 0.011）。Kerr® 树脂表现出更高的 Bis-GMA/UDMA 比率，尤其是在 BF 深树脂中 (p < 0.05)。3M® 和 Ivoclar 树脂的炎症评分不高，但 Kerr® BF 树脂（浅表和深层）的炎症过程明显高于 CR 和假象限（p = 0.031）。结论树脂接种后的组织炎症反应取决于Bis-GMA的DC和光固化残留物。与 BF-deep 相比，Ivoclar® 和 Kerr® 树脂在 CR 和 BF-表面显示出更高的 DC（p = 0.005 和 p = 0.011）。Kerr® 树脂表现出更高的 Bis-GMA/UDMA 比率，尤其是在 BF 深树脂中 (p < 0.05)。3M® 和 Ivoclar 树脂的炎症评分不高，但 Kerr® BF 树脂（浅表和深层）的炎症过程明显高于 CR 和假象限（p = 0.031）。结论树脂接种后的组织炎症反应取决于Bis-GMA的DC和光固化残留物。炎症过程明显高于 CR 和假象限 (p = 0.031)。结论树脂接种后的组织炎症反应取决于Bis-GMA的DC和光固化残留物。炎症过程明显高于 CR 和假象限 (p = 0.031)。结论树脂接种后的组织炎症反应取决于Bis-GMA的DC和光固化残留物。