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Visible Light-Induced Radical Addition/Annulation to Construct Phenylsulfonyl-Functionalized Dihydrobenzofurans Involving an Intramolecular 1,5-Hydrogen Atom Transfer Process
Organic Letters ( IF 5.2 ) Pub Date : 2020-11-04 , DOI: 10.1021/acs.orglett.0c03038
Shentong Xie 1 , Yifan Li 1 , Ping Liu 1 , Peipei Sun 1
Affiliation  

A visible light-induced radical cascade reaction of 2-alkynylarylethers with sodium sulfinates was established for the synthesis of sulfonyl-functionalized dihydrobenzofurans, and an intramolecular 1,5-hydrogen atom transfer was involved in this transformation. This process provided an efficient and convenient C–C formation protocol for the construction of a dihydrobenzofuran ring. Various substituents on 2-alkynylarylethers and sodium sulfinates were tolerated in the reaction, and the corresponding products were obtained in moderate to good yields.

中文翻译:

可见光诱导的自由基加法/环化反应,构建涉及分子内1,5-氢原子转移过程的苯磺酰基官能化二氢苯并呋喃

建立了可见光诱导的2-炔基芳基醚与亚磺酸钠的自由基级联反应,用于合成磺酰基官能化的二氢苯并呋喃,并且分子内的1,5-氢原子转移参与了该转化。该过程为构建二氢苯并呋喃环提供了有效而便捷的CC形成方案。反应中容许2-炔基芳基醚和亚磺酸钠上的各种取代基,并且以中等至良好的产率获得相应的产物。
更新日期:2020-11-21
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