Infection of skin injuries by pathogenic microbial strains is generally associated if not treated with a lasting wound bed oxidative stress status, a delay in healing process, and even wound chronicity with several human health complications. The aim of the current study was to explore the antioxidant and antimicrobial potentialities of safflower (Carthamus tinctorius L.) extracted oil from seeds by cold pressing which would be beneficial in the management of skin wounds. Antioxidant capacity of the oil was evaluated (scavenging ability against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP)). Total phenolic, total flavonoid, total carotenoid, and total chlorophyll contents were determined. Antimicrobial activities of safflower oil were tested against 10 skin pathogenic microorganisms: 4 bacterial strains (Escherichia coli, Enterobacter cloacae, Staphylococcus aureus, and Streptococcus agalactiae), 3 yeast species strains (Candida albicans, Candida parapsilosis, and Candida sake), and 3 fungi species (Aspergillus niger, Penicillium digitatum, and Fusarium oxysporum). A notable antioxidant capacity was demonstrated for the tested oil that exhibited moreover high antibacterial effects by both bacteriostatic and bactericidal pathways including lysozyme activity. An antifungal effect was further observed on the spore’s germination. Safflower oil could be considered as a good natural alternative remedy in the management of skin wounds and their possible microbial infections.

中文翻译：

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红花籽油在治疗皮肤损伤中的抗氧化和抗菌潜力

如果不进行治疗，病原微生物菌株引起的皮肤损伤通常会导致伤口床氧化应激状态持久、愈合过程延迟，甚至导致伤口慢性化并伴有多种人类健康并发症。本研究的目的是探索通过冷榨从种子中提取的红花油的抗氧化和抗菌潜力，这将有利于皮肤伤口的治疗。评估了油的抗氧化能力（对1,1-二苯基-2-三硝基苯肼自由基（DPPH）和2,2-叠氮基-双3-乙基苯并噻唑啉-6-磺酸（ABTS）的清除能力，以及铁的降低抗氧化能力（ FRAP））。测定总酚、总黄酮、总类胡萝卜素和总叶绿素含量。红花油对 10 种皮肤病原微生物的抗菌活性进行了测试：4 种细菌菌株（大肠杆菌、阴沟肠杆菌、金黄色葡萄球菌和无乳链球菌）、3 种酵母菌株（白色念珠菌、近平滑念珠菌和清酒念珠菌）和 3 种真菌种（黑曲霉、指状青霉和尖镰孢）。所测试的油具有显着的抗氧化能力，此外还通过抑菌和杀菌途径（包括溶菌酶活性）表现出高抗菌作用。进一步观察到对孢子萌发的抗真菌作用。红花油可被视为治疗皮肤伤口及其可能的微生物感染的良好天然替代疗法。