Background: Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system. Summary: This review provides an introduction to the current state-of-the-art in microbiome research both from the perspective of “what is known” and of methodologies for its investigation. It then summarises the evidence for a role for the microbiome in the pathogenesis of Graves’ disease and Graves’ orbitopathy with reference to animal models and studies in human cohorts, from both published and ongoing sources. Key Message: Microbiome research is in its infancy but has already provided novel insights into disease pathogenesis across the spectrum from cancer to mental health and autoimmunity.
Eur Thyroid J

中文翻译：

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微生物组和格雷夫斯眼眶病

背景：对自身免疫动物模型的研究强调了微生物及其代谢产物在塑造免疫系统方面的潜在重要性。摘要：本综述从“已知”和调查方法的角度介绍了当前微生物组研究的最新技术。然后，它参考动物模型和人类队列研究，总结了微生物组在 Graves 病和 Graves 眼眶病发病机制中作用的证据，这些证据来自已发表和正在进行的来源。关键信息：微生物组研究处于起步阶段，但已经为从癌症到心理健康和自身免疫的疾病发病机制提供了新的见解。
欧洲甲状腺杂志