Abstract

Two new metal-organic coordination compounds with the chemical formulae of [Zn(Htpt)]_n (1) and {[Zn(H₂tpt)(H₂O)]·1/2SO₄·2H₂O}_n (2) based on a multidentate 4-(2,4,6-tricarboxyphenyl)-2,2′,6,2″-terpyridine ligand (H₃tpt) have been prepared by hydrothermal synthesis method and structurally characterized. The treatment activity of the compounds on the peripheral artery disease was further explored in the biological section. Firstly, the real time reverse transcription-polymerase chain reaction (RT-PCR) was performed and the expression levels of the peptidyl arginine deiminase were measured. Then, the enzyme linked immunosorbent assay (ELISA) detection kit was used and the content of the inflammatory cytokines was determined.

摘要

化学式为[Zn(Htpt)] _n ( 1 ) 和{[Zn(H ₂ tpt)(H ₂ O)]·1/2SO ₄ ·2H ₂ O} _n ( 2 ) 基于多齿 4-(2,4,6-三羧基苯基)-2,2',6,2"-三联吡啶配体 (H ₃tpt) 已通过水热合成方法制备并进行了结构表征。在生物部分进一步探讨了化合物对外周动脉疾病的治疗活性。首先，进行实时逆转录聚合酶链反应 (RT-PCR) 并测量肽基精氨酸脱亚胺酶的表达水平。然后，使用酶联免疫吸附试验(ELISA)检测试剂盒测定炎性细胞因子的含量。