Organometallic compounds have become increasingly important in organic synthesis because of their high chemoselectivity and excellent reactivity. Recently, a variety of organometallic reagents were found to facilitate transition-metal-catalyzed cross-coupling reactions and nucleophilic addition reactions. Here, we have summarized the latest progress in cross-coupling reactions and in nucleophilic addition reactions with functionalized organometallic reagents present to illustrate their application value. Due to the tremendous contribution made by the Knochel group towards the development of novel organometallic reagents, this review draws extensively from their work in this area in recent years.

Introduction

1 Transition-Metal-Catalyzed Cross Couplings Involving Organo­zinc Reagents

2 Transition-Metal-Catalyzed Cross Couplings Involving Organomagnesium Reagents

3 Transition-Metal-Free Cross Couplings Involving Zn and Mg ­Organometallic Reagents

4 Nucleophilic Additions Involving Zn and Mg Organometallic Reagents

5 Cross-Coupling Reactions or Nucleophilic Additions Involving Mn, Al-, La-, Li-, Sm- and In-Organometallics

6 Conclusion

有机金属化合物因其高的化学选择性和出色的反应性而在有机合成中变得越来越重要。最近，发现各种有机金属试剂可促进过渡金属催化的交叉偶联反应和亲核加成反应。在这里，我们总结了交叉偶联反应和亲核加成反应与功能化有机金属试剂的最新进展，以说明其应用价值。由于Knochel小组对新型有机金属试剂的开发做出了巨大贡献，因此本文的综述广泛借鉴了他们近年来在这一领域的工作。

介绍

1种涉及有机锌试剂的过渡金属催化交叉偶联

2种涉及有机镁试剂的过渡金属催化交叉偶联

3种涉及锌和镁有机金属试剂的无过渡金属交叉偶联

4种涉及锌和镁有机金属试剂的亲核添加剂

5涉及锰，铝，镧，锂，锡和中有机金属的交叉偶联反应或亲核加成

六，结论