The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. A straightforward approach is reported for the scale-up of a [2+2] photocycloaddition step using convenient home-made flow photoreactors to access dimethyl 1,4-cubanedicarboxylate on decagram-scale in 33–40% yield over 8 steps. The process is demonstrated on 3.4 g·h^–1 input with 30 minutes residence time, enabling to reduce the process time and to avoid the use of batch photoreactors. Completion of the characterisation of the photocycloadduct and its hydrates is reported.

中文翻译：

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连续流光化学十进制合成1,4-Cubanedi羧酸二甲酯

作为药物和材料化学中的支架和刚性连接子，高度紧张的古巴体系引起了人们的极大兴趣。据报道，一种简便的方法可以扩大[2 + 2]光环加成步骤，使用方便的自制流动光反应器以十克级规模通过8个步骤以33–40％的产率获得1,4-嘧啶二甲酸二甲酯。以3.4 g·h ^–1的输入量和30分钟的停留时间演示了该工艺，从而减少了工艺时间并避免了使用间歇式光反应器。报道了光环加合物及其水合物的表征完成。