Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia‐induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT‐photosensitizer and on‐demand designed anticancer prodrug SN38‐Nif, which is released and activated by photothermia and tumor‐overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia‐induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.

中文翻译：

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负载前药的碳化锆纳米片作为有效治疗癌症的新型生物光子纳米平台

传统化疗和光热疗法（PTT）面临许多重大挑战，包括全身毒性、低生物利用度、无效的组织渗透、化疗/热疗诱导的炎症和肿瘤血管生成。多功能纳米医学提供了一个令人兴奋的机会来规避上述限制，使其成功转化为临床实践。在此，开发了一种有前景的生物光子纳米平台，基于碳化锆（ZrC）纳米片作为深度 PTT 光敏剂和按需设计的抗癌前药 SN38-Nif，该药物通过光热和肿瘤过度表达的酯酶释放和激活。体外和体内实验证据表明，集成的 ZrC@prodrug 生物光子纳米平台通过专门针对恶性细胞、化疗/热疗诱导的肿瘤炎症和血管生成，具有有效的抗癌作用。在小鼠模型中，ZrC@prodrug 系统显着抑制肿瘤复发、转移、炎症和血管生成。这些发现揭示了一种有前途的癌症精准治疗生物光子策略。