BACKGROUND For unknown reasons, Hispanic patients with cystic fibrosis (CF) have more severe pulmonary disease than non-Hispanic white patients. In CF, the pulmonary pathogen Pseudomonas aeruginosa is associated with worse outcomes. We sought to determine if Hispanic patients with CF are at an increased risk of acquiring P. aeruginosa or acquire it earlier than non-Hispanic white patients. METHODS This is a longitudinal study comparing the timing and risk of acquisition of different forms of P. aeruginosa between Hispanic and non-Hispanic white patients aged 0-21 years old with CF in the CF Foundation Patient Registry (CFFPR) in 2008-2013. The age at the initial acquisition of P. aeruginosa (initial acquisition, mucoid, chronic, multidrug-resistant) was summarized using Kaplan-Meier survival curves and analyzed using Cox proportional hazards regression models. RESULTS Of 10,464 patients, 788 (7.5%) were Hispanic and 9,676 (92.5%) were non-Hispanic white. Hispanic patients acquired all forms of P. aeruginosa at a younger age than non-Hispanic white patients. Hispanic patients had a higher risk of acquiring P. aeruginosa than non-Hispanic white patients: the hazard ratio (HR) was 1.26 (95% CI 1.16-1.38, p<0.001) for initial P. aeruginosa, 1.59 (95% CI 1.43-1.77, p<0.001) for mucoid P. aeruginosa, 1.91 (95% CI 1.64-2.23, p<0.001) for multidrug-resistant P. aeruginosa, and 1.39 (95% CI 1.25-1.55, p<0.001) for chronic P. aeruginosa. CONCLUSIONS Hispanic patients have an increased risk of acquiring P. aeruginosa and acquire it at an earlier age than non-Hispanic white patients in the United States. This may contribute to increased morbidity and mortality in Hispanic patients with CF.

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在美国患有囊性纤维化的西班牙裔青年早期获得和转化铜绿假单胞菌

背景由于未知原因，患有囊性纤维化 (CF) 的西班牙裔患者比非西班牙裔白人患者患有更严重的肺部疾病。在 CF 中，肺部病原体铜绿假单胞菌与较差的结果相关。我们试图确定西班牙裔 CF 患者感染铜绿假单胞菌的风险是否高于非西班牙裔白人患者。方法 这是一项纵向研究，比较了 2008-2013 年 CF 基金会患者登记处 (CFFPR) 中 0-21 岁的 CF 西班牙裔和非西班牙裔白人患者获得不同形式的铜绿假单胞菌的时间和风险。初次感染铜绿假单胞菌的年龄（初次感染、粘液性、慢性、多药耐药）使用 Kaplan-Meier 生存曲线进行总结，并使用 Cox 比例风险回归模型进行分析。结果 在 10,464 名患者中，788 名（7.5%）为西班牙裔，9,676 名（92.5%）为非西班牙裔白人。西班牙裔患者比非西班牙裔白人患者在更年轻时获得所有形式的铜绿假单胞菌。西班牙裔患者感染铜绿假单胞菌的风险高于非西班牙裔白人患者：初始铜绿假单胞菌的风险比 (HR) 为 1.26 (95% CI 1.16-1.38, p<0.001)，1.59 (95% CI 1.43) -1.77, p<0.001) 粘液性铜绿假单胞菌，1.91 (95% CI 1.64-2.23, p<0.001) 耐多药铜绿假单胞菌，1.39 (95% CI 1.25-1.55, p<0.001) 慢性铜绿假单胞菌。结论 西班牙裔患者感染 P 的风险增加。铜绿假单胞菌的发病年龄比美国的非西班牙裔白人患者更早。这可能会增加西班牙裔 CF 患者的发病率和死亡率。