Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

中文翻译：

---

脆性X综合征的线粒体功能障碍：堵漏可能会救船

Licznerski等人的最新工作。提示与脆性X综合征相关的突变FMRP加剧了线粒体内膜质子泄漏，导致新陈代谢增加和蛋白质合成发生变化，从而触发突触成熟和自闭症行为。