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Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma
iScience ( IF 5.8 ) Pub Date : 2020-11-05 , DOI: 10.1016/j.isci.2020.101770
Erin A Akins 1, 2 , Manish K Aghi 3 , Sanjay Kumar 1, 2, 4
Affiliation  

Tumor progression is profoundly influenced by interactions between cancer cells and the tumor microenvironment (TME). Among the various non-neoplastic cells present, immune cells are critical players in tumor development and have thus emerged as attractive therapeutic targets. Malignant gliomas exhibit a unique immune landscape characterized by high numbers of tumor-associated macrophages (TAMs). Despite encouraging preclinical results, targeting TAMs has yielded limited clinical success as a strategy for slowing glioma progression. The slow translational progress of TAM-targeted therapies is due in part to an incomplete understanding of the factors driving TAM recruitment, differentiation, and polarization. Furthermore, the functions that TAMs adopt in gliomas remain largely unknown. Progress in addressing these gaps requires sophisticated culture platforms capable of capturing key cellular and physical TME features. This review summarizes the current understanding of TAMs in gliomas and highlights the utility of in vitro TME models for investigating TAM-cancer cell cross talk.



中文翻译:

将肿瘤相关巨噬细胞纳入胶质瘤工程模型

肿瘤进展受到癌细胞与肿瘤微环境(TME)之间相互作用的深刻影响。在存在的各种非肿瘤细胞中,免疫细胞是肿瘤发展的关键参与者,因此已成为有吸引力的治疗靶点。恶性胶质瘤表现出独特的免疫景观,其特征是大量肿瘤相关巨噬细胞(TAM)。尽管临床前结果令人鼓舞,但靶向 TAM 作为减缓神经胶质瘤进展的策略在临床上取得的成功有限。TAM 靶向治疗的转化进展缓慢,部分原因是对驱动 TAM 募集、分化和极化的因素了解不完全。此外,TAM 在神经胶质瘤中发挥的功能仍然很大程度上未知。要解决这些差距,需要能够捕获关键细胞和物理 TME 特征的复杂培养平台。这篇综述总结了目前对神经胶质瘤中 TAM 的理解,并强调了体外TME 模型在研究 TAM-癌细胞串扰方面的实用性。

更新日期:2020-11-23
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