OBJECTIVE Poliomyelitis results in changes to the anterior horn cell. The full extent of cortical network changes in the motor physiology of polio survivors has not been established. Our aim was to investigate how focal degeneration of the lower motor neurons (LMN) in infancy/childhood affects motor network connectivity in adult survivors of polio. METHODS Surface electroencephalography (EEG) and electromyography (EMG) were recorded during an isometric pincer grip task in 25 patients and 11 healthy controls. Spectral signal analysis of cortico-muscular (EEG-EMG) coherence (CMC) was used to identify the cortical regions that are functionally synchronous and connected to the periphery during the pincer grip task. RESULTS A pattern of CMC was noted in polio survivors that was not present in healthy individuals. Significant CMC in low gamma frequency bands (30-47 Hz) was observed in frontal and parietal regions. CONCLUSION These findings imply a differential engagement of cortical networks in polio survivors that extends beyond the motor cortex and suggest a disease-related functional reorganisation of the cortical motor network. SIGNIFICANCE This research has implications for other similar LMN conditions, including spinal muscular atrophy (SMA). CMC has potential in future clinical trials as a biomarker of altered function in motor networks in post-polio syndrome, SMA, and other related conditions.

中文翻译：

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脊髓灰质炎幸存者的脊髓上运动网络改变：皮质-肌肉一致性研究

目的 脊髓灰质炎会导致前角细胞发生变化。脊髓灰质炎幸存者运动生理学的皮质网络变化的全部范围尚未确定。我们的目的是研究婴儿期/儿童期下运动神经元 (LMN) 的局灶性退化如何影响成年脊髓灰质炎幸存者的运动网络连接。方法 在 25 名患者和 11 名健康对照者的等距钳夹任务期间记录表面脑电图 (EEG) 和肌电图 (EMG)。皮质肌肉 (EEG-EMG) 相干性 (CMC) 的频谱信号分析用于识别在钳夹任务期间功能同步并连接到外围的皮质区域。结果 在脊髓灰质炎幸存者中发现了一种 CMC 模式，而在健康个体中则不存在。在额叶和顶叶区域观察到低伽马频带 (30-47 Hz) 中的显着 CMC。结论这些发现意味着脊髓灰质炎幸存者的皮层网络的不同参与超出了运动皮层，并表明皮层运动网络的疾病相关功能重组。意义 这项研究对其他类似的 LMN 疾病有影响，包括脊髓性肌萎缩症 (SMA)。CMC 在未来的临床试验中具有作为脊髓灰质炎后综合征、SMA 和其他相关疾病运动网络功能改变的生物标志物的潜力。结论这些发现意味着脊髓灰质炎幸存者的皮层网络的不同参与超出了运动皮层，并表明皮层运动网络的疾病相关功能重组。意义 这项研究对其他类似的 LMN 疾病有影响，包括脊髓性肌萎缩症 (SMA)。CMC 在未来的临床试验中具有作为脊髓灰质炎后综合征、SMA 和其他相关疾病运动网络功能改变的生物标志物的潜力。结论这些发现意味着脊髓灰质炎幸存者的皮层网络的不同参与超出了运动皮层，并表明皮层运动网络的疾病相关功能重组。意义 这项研究对其他类似的 LMN 疾病有影响，包括脊髓性肌萎缩症 (SMA)。CMC 在未来的临床试验中具有作为脊髓灰质炎后综合征、SMA 和其他相关疾病运动网络功能改变的生物标志物的潜力。