Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.

中文翻译：

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血管生成和炎症肿瘤的演变：肾癌范例

基因表达分析已经确定了广泛分布在血管生成和增殖/免疫原性进化枝中的常规肾细胞癌的亚型。与动物模型中的基因组和功能实验相结合产生了一个进化模型。进化轨迹说明了显着的可塑性，特别是对于通常以单个基因失活开始的肿瘤。