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The Novel Target of Colorectal Carcinoma: TRIM44 Regulates Cell Migration and Invasion via Activation of CXCR4/NF-κB Signaling
Cell Biochemistry and Biophysics ( IF 2.6 ) Pub Date : 2020-11-05 , DOI: 10.1007/s12013-020-00955-w
Tianlei Kou 1 , Deqian Sha 2 , Fei Wang 3 , Tao He 1 , Xuan He 1
Affiliation  

Tripartite motif containing 44 (TRIM44) has been reported to regulate various biological effects in malignant cancers and matrix Metalloproteinases has been demonstrated to be associated with cancer cell migration and invasion. Nonetheless, the expression and molecular mechanism of TRIM44 in colorectal cancer (CRC) remain rarely known. TRIM44 was overexpressed or knocked down in CRC cells. Subsequently, the effects of TRIM44 on cell migration and invasion as well as underlying molecular mechanisms were detected. Data showed that TRIM44 was highly expressed in CRC cell lines. Downregulation of TRIM44 inhibited the cell viability, migration, and invasion in SW-480 cells. In addition, overexpression of TRIM44 enhanced the expression of NF-κB and CXCR4, and enhanced the binding between NF-κB and CXCR4 promoter region. In summarize, TRIM44 may serve as a potential target for CRC diagnosis and progression.



中文翻译:

大肠癌的新型靶标:TRIM44通过激活CXCR4 /NF-κB信号调节细胞迁移和侵袭

据报道,含有44(TRIM44)的三方基序可调节恶性癌症中的多种生物学作用,并且已证明基质金属蛋白酶与癌细胞的迁移和侵袭有关。尽管如此,TRIM44在结直肠癌(CRC)中的表达及其分子机制仍然鲜为人知。TRIM44在CRC细胞中过表达或被敲低。随后,检测到TRIM44对细胞迁移和侵袭的影响以及潜在的分子机制。数据显示TRIM44在CRC细胞系中高表达。TRIM44的下调抑制了SW-480细胞中的细胞活力,迁移和侵袭。另外,TRIM44的过表达增强了NF-κB和CXCR4的表达,并增强了NF-κB和CXCR4启动子区域之间的结合。总而言之,

更新日期:2020-11-06
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