Abstract

An inactivated vaccine based on the Sal. abortus equi BN-12 strain with the Bac. subtilis TNP-3 strain filtrate used as immunomodulator has been developed in order to prevent salmonella-induced equine abortion. Preclinical and clinical trials with the white mice and the horses, respectively, are carried out. The lack of toxicity is proven. The vaccine immunogenicity for mouse and mare models comprised 90 and 100%, respectively. The industrial vaccine tests showed that the industrial output of foals increased by 13.8% after immunization. Cost-effectiveness of the vaccine used with the Bac. subtilis TNP-3 strain filtrate comprised 14.1 rubles per 1 ruble of costs, which was 1.8-fold greater when compared to the vaccine used with a polyribonate medicine. It is ascertained that administration of the inactivated vaccine with the Bac. subtilis TNP-3 strain is an effective method to prevent infectious abortion. Scientific and technical documentation is developed based on the survey results in order to submit it for approval to the Rosselkhoznadzor Federal Service for Veterinary and Phytosanitary Surveillance. The instruction is compliant with the approved use. The registration certificate (71-1-10.19-4495 no. PVR-1-1-.6/01631, as of June 10, 2019) has been issued.

中文翻译：

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沙门氏菌引起的马堕胎疫苗的开发结果。

摘要

基于Sal的灭活疫苗。用Bac进行BN-12流产。已开发了用作免疫调节剂的枯草杆菌TNP-3菌株滤液，以防止沙门氏菌引起的马流产。分别对白色小鼠和马进行了临床前和临床试验。证明没有毒性。小鼠和母马模型的疫苗免疫原性分别为90％和100％。工业疫苗测试表明，免疫后小马驹的工业产量提高了13.8％。与Bac一起使用的疫苗的成本效益。枯草杆菌TNP-3菌株滤液的成本为每1卢布14.1卢布，这与使用多核糖酸盐药物的疫苗相比要高1.8倍。可以确定灭活疫苗与Bac一起给药。枯草杆菌TNP-3菌株是预防感染性流产的有效方法。根据调查结果制定科学和技术文档，以将其提交给Rosselkhoznadzor联邦兽医和植物检疫监督局。该说明符合批准的使用方式。颁发了注册证书（截至2019年6月10日的71-1-10.19-4495编号PVR-1-1-.6 / 01631）。