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Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications
Stem Cell Reviews and Reports ( IF 4.8 ) Pub Date : 2020-11-05 , DOI: 10.1007/s12015-020-10075-w
Malak El Sabeh 1 , Sadia Afrin 1 , Bhuchitra Singh 1 , Mariko Miyashita-Ishiwata 1 , Mostafa Borahay 1
Affiliation  

Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, endometriosis and adenomyosis. Current evidence suggests the conversion of uterine stem cells to tumor initiating stem cells in leiomyomas, endometriosis stem cells, and adenomyosis stem cells, acquiring genetic and epigenetic alterations for the progression of each benign condition. In this comprehensive review, we aim to summarize the progress that has been made to characterize the involvement of stem cells in the pathogenesis of benign gynecologic conditions which, despite their enormous burden, are not yet fully understood. We focus on the stem cell characteristics and aberrations that contribute to the development of benign gynecological disorders and the possible clinical implications of what is known so far. Lastly, we discuss the role of uterine stem cells in the setting of regenerative medicine, particularly in the treatment of Asherman syndrome.

Graphical abstract



中文翻译:

子宫干细胞和良性妇科疾病:在病理生物学和治疗意义中的作用

子宫内膜和子宫肌层中的干细胞具有巨大的再生潜力,这是维持月经周期和支持怀孕所必需的。这些细胞以及骨髓干细胞也与常见的良性妇科疾病的发展有关,包括平滑肌瘤、子宫内膜异位症和子宫腺肌病。目前的证据表明,子宫干细胞转化为平滑肌瘤、子宫内膜异位症干细胞和子宫腺肌病干细胞中的肿瘤起始干细胞,获得了每种良性疾病进展的遗传和表观遗传改变。在这篇全面的综述中,我们旨在总结在描述干细胞参与良性妇科疾病的发病机制方面所取得的进展,尽管它们的负担很大,但尚未完全了解。我们专注于有助于良性妇科疾病发展的干细胞特征和异常以及迄今为止已知的可能的临床意义。最后,我们讨论了子宫干细胞在再生医学中的作用,特别是在治疗 Asherman 综合征方面。

图形概要

更新日期:2020-11-06
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