Emotional disturbances emerge following alcohol withdrawal. The anxiolytic effect of alcohol may be one important motivation for its consumption in conditions where alcohol intake is anxiety reducing. Besides, early alcohol experience will predict future alcohol-related problems at some point in their lives. Rats classified according to their anxiety-like behavior phenotype show a higher preference for alcohol. Yet, despite preclinical studies have identified the behavioral and physiological effects of alcohol withdrawal, little has been shown on relapse to alcohol after a period of abstinence following intermittent long-term alcohol consumption in low-(LA) and high-anxiety (HA) phenotype rats. This study attempts to assess the role of emotional reactivity of early-aged LA and HA rats on later alcohol preference, through an operant response procedure. For this, a sweetened liquid fading procedure associated with a long-term and intermittent voluntary alcohol drinking was used, with the animals being tested on different withdrawal periods. Alcohol withdrawal symptoms were recorded, and blood alcohol levels were assessed at two intervals to examine the influence of anxiety phenotype on blood alcohol clearance. Data from HA control and HA withdrawn rats show that emotionality selectively influences alcohol preference. Blood alcohol decay was faster in HA than in LA alcohol pretreated rats. HA rats showed an ascending curve of alcohol intake, exhibiting a high level of alcohol drinking on withdrawal and withdrawal symptoms. Moreover, HA alcohol experienced rats show a high frequency of lever-pressing response during extinction, associated with a facilitation of bar-pressing recovery trials, an indication of alcohol-seeking behavior.

戒酒后出现情绪障碍。在酒精摄入减少的情况下，酒精的抗焦虑作用可能是其消费的重要动机。此外，早期的饮酒经验将在他们生活中的某个时刻预测未来与酒精有关的问题。根据其焦虑样行为表型分类的大鼠对酒精的偏爱更高。然而，尽管临床前研究已经证实了戒酒的行为和生理学影响，但在低（LA）和高焦虑（HA）表型间歇长期长期饮酒后禁酒一段时间后，对酒精复发的研究很少。大鼠。这项研究试图评估早期LA和HA大鼠情绪反应对以后的酒精偏好的作用，通过操作响应程序。为此，使用了与长期和间歇性自愿饮酒有关的甜味液体褪色程序，并在不同的停药期对动物进行了测试。记录戒酒症状，并在两个间隔内评估血液酒精水平，以检查焦虑表型对血液酒精清除率的影响。来自HA对照和HA撤回大鼠的数据表明，情绪选择性地影响酒精偏好。HA中的血液酒精衰减比LA酒精预处理的大鼠快。HA大鼠的酒精摄入量呈上升曲线，出现戒断和戒断症状时饮酒量较高。此外，有HA酒精经验的大鼠在灭绝过程中显示出较高的杠杆按压反应频率，