Although children with novel coronavirus infection (COVID-19) typically present with fever and respiratory symptoms, some children have reported gastrointestinal (GI) symptoms including vomiting and diarrhoea during the course of the disease. The continuous positive detection of the viral RNA from faeces in children even after nasopharyngeal swabs turned negative suggests that the GI tract may shed virus and a tentative faecal–oral transmission. The presence of angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2, which are the key proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry process, in the GI tract can explain the digestive symptoms in COVID-19. COVID-19 has implications for the management of children with chronic luminal diseases. There is increasing concern regarding the risk that children with inflammatory bowel disease being infected with SARS-CoV-2.


中文翻译：

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儿科 COVID-19 和 GUT


尽管新型冠状病毒感染 (COVID-19) 的儿童通常会出现发烧和呼吸道症状，但一些儿童在疾病过程中报告了胃肠道 (GI) 症状，包括呕吐和腹泻。即使在鼻咽拭子转为阴性后，儿童粪便中病毒 RNA 的持续阳性检测表明，胃肠道可能会传播病毒和暂时的粪口传播。血管紧张素转换酶2受体和跨膜丝氨酸蛋白酶2是严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）细胞进入过程的关键蛋白，在胃肠道中的存在可以解释COVID- 19. COVID-19 对患有慢性管腔疾病的儿童的管理有影响。