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Epidemiological pattern of Malassezia, its phenotypic identification and antifungal susceptibility profile to azoles by broth microdilution method
Indian Journal of Medical Microbiology ( IF 1.6 ) Pub Date : 2020-07-01 , DOI: 10.4103/ijmm.ijmm_20_106
Packia Nancy Romald 1 , Anupma Jyoti Kindo 1 , V Mahalakshmi 2 , U Umadevi 3
Affiliation  


Background: Malassezia though known for its cutaneous infections can potentially cause invasion. The skin infections caused by Malassezia have poor patient compliance due to its chronicity and recurrent nature of the disease. There is also a lack of standardised antifungal susceptibility profile for Malassezia due to its complex growth requirement. Objective: This study was performed to understand the epidemiological pattern of disease and to study the antifungal susceptibility testing (AFST) profile so as to choose the appropriate drug/drugs to treat the infections caused by Malassezia. Materials and Methods: Samples were collected and processed, species were identified by conventional method and AFST was done by broth microdilution method. Results: The epidemiological pattern showed adolescent females commonly affected in torso. The most common lesion was pityriasis versicolor. The systemic antifungal of choice was itraconazole with the lowest minimum inhibitory concentration (MIC) of 0.125–1 μg/ml. The best topical drug with the lowest MIC value was clotrimazole 0.03–0.5 μg/ml. Conclusion: AFST is important as it will help the dermatologist to choose the appropriate antifungal agents for the patient and thereby reduce the chronicity of the disease with good patient compliance


中文翻译:

马拉色菌的流行病学模式、表型鉴定和肉汤微量稀释法对唑类的抗真菌药敏性


背景: 马拉色菌虽然以其皮肤感染而闻名,但可能会导致入侵。由于马拉色菌引起的皮肤感染具有慢性和复发性,因此患者依从性差。由于其复杂的生长要求,马拉色菌也缺乏标准化的抗真菌药敏谱。目的:本研究旨在了解疾病的流行病学模式并研究抗真菌药敏试验 (AFST) 特征,以便选择合适的药物/药物来治疗马拉色菌引起的感染。材料和方法:样品采集和处理,物种鉴定采用常规方法,AFST采用肉汤微量稀释法。结果:流行病学模式显示青春期女性通常受躯干影响。最常见的病变是花斑癣。选择的全身性抗真菌药是伊曲康唑,最低抑菌浓度 (MIC) 为 0.125–1 μg/ml。MIC 值最低的最佳外用药物是克霉唑 0.03–0.5 μg/ml。结论: AFST 很重要,因为它将帮助皮肤科医生为患者选择合适的抗真菌药物,从而在患者依从性良好的情况下减少疾病的慢性化
更新日期:2020-07-01
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