The ability of probiotic bacteria to colonise the target site is considered of utmost importance and used for preliminary screening of potential probiotic candidates. Thirty-eight vaginal Lactobacillus strains isolated from healthy women and characterised by 16S RNA sequencing were assessed for colonisation characteristics including adherence to human vaginal epithelial cells, auto-aggregation and hydrophobicity. No significant difference in adherence (P = 0.384), auto-aggregation (P = 0.282) and hydrophobicity (P = 0.084) abilities between Lactobacillus species was observed, however, significant difference in colonisation characteristics between strains of the same species was noted (P < 0.001). We identified seven Lactobacillus strains that may serve as best candidates for vaginal probiotic development.


中文翻译：

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健康印度女性阴道乳酸杆菌定植特性的表征：对潜在益生菌候选物的鉴定的意义


益生菌在目标部位定殖的能力被认为是最重要的，可用于初步筛选潜在的益生菌候选物。对从健康女性中分离并通过 16S RNA 测序表征的38株阴道乳杆菌进行定植特征评估，包括对人阴道上皮细胞的粘附、自动聚集和疏水性。观察到乳酸杆菌属物种之间的粘附性（P = 0.384）、自动聚集（P = 0.282）和疏水性（P = 0.084）能力没有显着差异，但是，注意到同一物种菌株之间的定殖特征存在显着差异（P< 0.001)。我们确定了七种乳酸杆菌菌株，它们可能是阴道益生菌开发的最佳候选者。