In this study, a sensitive and selective sensor is constructed to measure the melamine (MEL) using molecular imprinting polymer (MIP) technique. Chemical and electrochemical techniques are used to construct the MIP and quantitative measurements. The constructed sensor was modified with GO-Fe₃O₄@SiO₂ nanocomposite. Screening and optimization of factors are done using statistical methods, including Plackett–Burman design (PBD) and central composite design (CCD). Under the optimized conditions, an MIP sensor showed a linear range from 5.0 × 10⁻⁷ to 1.0 × 10⁻⁵ M MEL concentration with a correlation coefficient (R²) of 0.9997. The limit of detection was obtained (0.028 µM) with a highly reproducible response (RSD 2.15%, n = 4). The electrochemical sensor showed good results for the determination of MEL in food samples.

中文翻译：

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三聚氰胺识别：分子印迹聚合物，用于食品样品中三聚氰胺的选择性和灵敏测定

在这项研究中，使用分子印迹聚合物（MIP）技术构建了灵敏且选择性的传感器来测量三聚氰胺（MEL）。化学和电化学技术用于构建MIP和定量测量。构造的传感器用GO-Fe ₃ O ₄ @SiO ₂纳米复合材料改性。使用统计方法进行因素的筛选和优化，包括Plackett-Burman设计（PBD）和中央复合设计（CCD）。在最佳条件下，MIP传感器的 MEL浓度线性范围为5.0×10 ^-7至1.0×10 ^-5 M，相关系数（R ²）为0.9997。获得了检出限（0.028 µ M）具有高度可重复的响应（RSD 2.15％，n  = 4）。电化学传感器对食品样品中的MEL含量测定具有良好的结果。