ABSTRACT

The present study concerned with the use of an aqueous ginger extract as naturally and eco-friendly reducing and stabilizing agent in the synthesis of silver nanoparticles (AgNPs). The unique physicochemical characteristics of green synthesized AgNPs exhibit high potential antimicrobial activity and displayed an impact role in pharmaceutical determinations. To confirm the nanoscale of green synthesized AgNPs, various microscopic and spectroscopic techniques were performed. The synthesized nanoparticles were screened for their antimicrobial activity against several strains of bacteria and fungi. The obtained results showed excellent bactericidal and fungicidal effects. Also, the spectrofluorimetric analysis of anastrozole drug in bulk powder and dosage form was investigated. The suggested method displayed linear relationship between the drug concentrations and the fluorescence intensity between 2 and 100 µgmL⁻¹ with regression equation was I _FL = 9.1917C+ 65.945, n = 10 and r = 0.9995 at λ_ex390 and λ_em 440 nm. The green synthesized AgNPs using ginger extract demonstrated a potential activity in pharmaceutical and biomedical fields.

摘要

本研究涉及在合成纳米银（AgNPs）中使用姜水提取物作为天然和生态友好型还原和稳定剂。绿色合成AgNP的独特理化特性显示出高潜在的抗菌活性，并在药物测定中显示出重要作用。为了确认绿色合成AgNPs的纳米级，进行了各种显微镜和光谱技术。筛选合成的纳米颗粒对几种细菌和真菌菌株的抗菌活性。所获得的结果显示出优异的杀菌和杀真菌效果。此外，还研究了散装粉末和剂型中阿那曲唑药物的荧光光谱法分析。带有回归方程的^-1 为_λex 390和_λem 440 nm时I _FL  = 9.1917C + 65.945，n  = 10，r = 0.9995 。使用生姜提取物的绿色合成AgNPs在制药和生物医学领域表现出潜在的活性。