Abstract

The objective of the study was to investigate the association of blood glucose and lipid profile parameters with cognitive impairment in schizophrenia. A total of 200 schizophrenia patients and 169 controls were enrolled in the study. Blood glucose and lipid profile were estimated in all the subjects. Cognition was assessed using Addenbrooke cognitive examination-III (ACE-III). Fasting glucose (p ≤ .001) and triacylglycerol (p = .018) were increased and HDL-Cholesterol (p ≤ .001), was reduced in schizophrenia. Glucose (r = −0.158, p = .026), total cholesterol (r = −0.249, p = .0001) and triacylglycerol (r = −0.168, p = .018) was negatively correlated with total ACE III score. Triacylglycerol (p = .041) was elevated in cases with mild cognitive impairment. Plasma glucose, total cholesterol and triacylglycerol were associated with various cognitive domains suggesting that hyperglycaemia and hyperlipidaemia might increase the risk of cognitive impairment in schizophrenia.

摘要

该研究的目的是调查血糖和血脂参数与精神分裂症认知障碍之间的关系。共有 200 名精神分裂症患者和 169 名对照者参加了这项研究。对所有受试者的血糖和血脂进行了评估。使用 Addenbrooke 认知检查-III (ACE-III) 评估认知。精神分裂症患者的空腹血糖 ( p  ≤ .001) 和三酰甘油 ( p  = .018) 升高，HDL-胆固醇 ( p  ≤ .001) 降低。葡萄糖 ( r  = −0.158, p  = .026)、总胆固醇 ( r  = −0.249, p  = .0001) 和三酰甘油 ( r  = −0.168, p = .018) 与 ACE III 总分呈负相关。三酰甘油 ( p  = .041) 在轻度认知障碍患者中升高。血浆葡萄糖、总胆固醇和甘油三酯与各种认知领域相关，这表明高血糖和高脂血症可能会增加精神分裂症认知障碍的风险。