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In vivo gastroprotective effect and biological potentialities of six Tunisian medicinal plants using multivariate data treatment
Plant Biosystems ( IF 2 ) Pub Date : 2020-11-17 , DOI: 10.1080/11263504.2020.1845840
Rim Ben Mansour 1 , Hanen Wasli 1, 2 , Raja Serairi-Beji 1, 3 , Soumaya Bourgou 1 , Sarra Dakhlaoui 1 , Sawssen Selmi 1 , Saber Khamessi 1 , Majdi Hammami 1 , Riadh Ksouri 1 , Wided Megdiche-Ksouri 1
Affiliation  

Abstract

Six Tunisian medicinal plants were screened for their phenolic pools, antioxidant activities as well as for their anti-inflammatory and gastro-protective effects. A significant variability in phenolic composition and antioxidant capacities between species were observed. Myrtus communis L. exhibited the highest phenolic contents and composition as well as the best potential antioxidant capacities as rescued by the lowest IC50 and EC50 values. On other hand, the common species excepting Juniperus phoenicea L. showed a noteworthy to moderate anti-inflammatory activity inhibiting NO release with an IC50 values ranging from 26 to 240 µg/mL. In turn, in vivo gastro-protective effect following HCl/EtOH induced ulcer models displayed that M. communis extract had an important inhibition of gastric lesions correlated to high healing and protection percentages. The visualized data were treated by PCA and Bi-plot analysis which highlighted a positive correlation among phenolic pools and antioxidant activities particularly in M. communis. Besides, statistic clustering allowed us to detect a strong contribution of phenol and flavonoid pools with anti-inflammatory and anti-ulcerogenic effects. Overall, the results obtained in this work indicated that the studied species, particularly Myrtus communis, represent a valuable source of natural agents beneficial for human health in particular for inflammation and gastric diseases.



中文翻译:

使用多元数据处理的六种突尼斯药用植物的体内胃保护作用和生物学潜力

摘要

筛选了六种突尼斯药用植物的酚类库、抗氧化活性以及抗炎和胃保护作用。观察到物种间酚类成分和抗氧化能力的显着差异。金娘展示出最高的酚类含量和组成,以及由最低的 IC 50和 EC 50值拯救的最佳潜在抗氧化能力。另一方面,除了杜松属 phoenicea L. 之外的常见物种表现出显着至中等的抗炎活性,抑制 NO 释放,IC 50值范围为 26 至 240 µg/mL。反过来,在体内HCl/EtOH 诱导的溃疡模型后的胃保护作用表明,M. Communis提取物对胃损伤具有重要的抑制作用,与​​高愈合和保护百分比相关。可视化数据通过 PCA 和 Bi-plot 分析处理,突出了酚类库和抗氧化活性之间的正相关,特别是在M.communis中。此外,统计聚类使我们能够检测到苯酚和类黄酮池具有抗炎和抗溃疡作用的强大贡献。总体而言,在这项工作中获得的结果表明,所研究的物种,特别是桃金娘,代表对人类健康特别是炎症和胃病有益的天然物质的宝贵来源。

更新日期:2020-11-17
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