Electronic nicotine delivery systems (ENDS; i.e., electronic cigarettes, e-cigarettes, vaping devices, vape pens) were introduced to the U.S. market in 2007 as a potential harm reduction alternative for people who smoked combustible cigarettes. Since that time, ENDS popularity grew very quickly, particularly among individuals who smoke cigarettes. However, young people and never smokers also started using ENDS, cohorts for whom these products were not intended. There are now a broad range of devices and e-liquid constituents. ENDS devices vary considerably in their design and generation of potentially toxic chemicals, with higher power devices likely much more hazardous than lower power devices. This landscape may further change after September 9, 2020, when all ENDS manufacturers are required to submit a premarket tobacco product application to the FDA to obtain authorization for marketing. Research has not kept pace with this rapidly changing technology and important questions remain regarding the relative benefits versus risks of ENDS. In light of these challenges, we propose key ENDS research priorities to address these gaps.

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消除阴霾：关于电子尼古丁输送系统我们还需要了解什么？

电子尼古丁输送系统（ENDS；即电子烟、电子烟、电子烟装置、电子烟笔）于 2007 年引入美国市场，作为吸食可燃香烟的人的潜在减害替代品。从那时起，电子尼古丁传送系统的受欢迎程度迅速增长，特别是在吸烟者中。然而，年轻人和从不吸烟的人也开始使用 ENDS，这些产品不适合这些人群。现在有各种各样的设备和电子烟液成分。ENDS 设备的设计和潜在有毒化学品的产生差异很大，较高功率的设备可能比较低功率的设备危险得多。2020 年 9 月 9 日之后，这种情况可能会进一步改变，届时所有 ENDS 制造商都必须向 FDA 提交上市前烟草产品申请以获得营销授权。研究未能跟上这种快速变化的技术的步伐，关于电子尼古丁传送系统的相对效益与风险的重要问题仍然存在。鉴于这些挑战，我们提出了电子尼古丁传送系统的主要研究重点，以弥补这些差距。