The tandem cyclization of acrylamide with diselenides facilitated by electrochemical oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C−Se bond. A series of seleno oxindoles with pharmacological activity were obtained by using this well‐designed tandem cyclization strategy. The in vitro antitumor activity of the compounds was also screened through MTT assay. Results showed that the seleno oxindoles exhibited better antitumor activity than other oxindole derivatives.

中文翻译：

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N-芳基丙烯酰胺与二有机基二硒化物的电化学环化合成硒代氧化吲哚

已成功开发了通过电化学氧化促进二硒化物与丙烯酰胺的串联环化反应。该策略为构建C-Se键提供了一种环境友好的方法。通过使用这种精心设计的串联环化策略，获得了一系列具有药理活性的硒代吲哚。在体外的化合物的抗肿瘤活性也通过MTT测定法进行筛选。结果表明，硒代羟吲哚比其他羟吲哚衍生物具有更好的抗肿瘤活性。