To solve the problems of limited drug solubility and poor biodistribution with polymers in drug delivery system, ibuprofen (IBU) is chosen to prepare IBU‐loaded poly(lactic acid) (PLA) micro‐fibrous mats via electrospinning. Distinguished from the previous studies, a lower toxic binary solvent dichloromethane/ethanol (DCM/EtOH, v/v = 8/2) is used to successfully fabricate PLA/IBU electrospun mats with outstanding properties. In order to further evaluate the effects of IBU content on PLA, there are characterization methods employed as follows: scanning electron microscopy (SEM), Fourier‐transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), differential scanning calorimetry (DSC), and UV–vis spectrophotometer. The results show that IBU can be physically and uniformly distributed both on the surface and inside of PLA fibers. Compared with pure PLA mats, the crystallinity and mechanical properties of PLA/IBU electrospun mats has significantly improved. Meanwhile, in vitro drug release behavior demonstrates that with the increasing content of IBU, the rate of IBU release has increasingly improved. Particularly, the release behavior of PLA/IBU mats exhibited best with 20% IBU content, and the release amount reached 74.3% at the end of 240 h. Considering all these features, PLA/IBU electrospun mats have the potential to be used in the fields of wound dressing and drug delivery.

中文翻译：

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布洛芬负载的聚乳酸静电纺垫：形态，理化性能和体外药物释放行为

为解决药物溶解度受限和药物在输运系统中聚合物分布不佳的问题，选择布洛芬（IBU）通过静电纺丝制备IBU负载的聚乳酸（PLA）微纤维垫。与以前的研究不同的是，毒性较低的二元溶剂二氯甲烷/乙醇（DCM / EtOH，v / v = 8/2）用于成功制造具有卓越性能的PLA / IBU电纺垫。为了进一步评估IBU含量对PLA的影响，采用了以下表征方法：扫描电子显微镜（SEM），傅立叶变换红外（FTIR）光谱，X射线衍射（XRD），差示扫描量热法（DSC） ）和紫外可见分光光度计。结果表明，IBU可以在PLA纤维的表面和内部均匀地物理分布。与纯PLA垫相比，PLA / IBU电纺垫的结晶度和机械性能有了显着提高。同时，体外药物释放行为表明，随着IBU含量的增加，IBU的释放速率也逐渐提高。尤其，IBU含量为20％时，PLA / IBU垫的释放行为表现最好，在240 h结束时释放量达到74.3％。考虑到所有这些功能，PLA / IBU电纺垫具有在伤口敷料和药物输送领域中使用的潜力。