Asthma is an allergic chronic inflammatory disease of the pulmonary airways, characterized by the infiltration of white blood cells and release of inflammatory cytokines of complex pathways linked to its pathogenesis. Syringin extracted from various medicinal plants has been used extensively for the treatment of inflammatory diseases. Hence, this study was conducted to further explore the protective effects of the syringin in ovalbumin (OVA) induced-asthma mice model. OVA-sensitized BALB mice were treated intraperitonealy with three doses (25, 50 and 100 mg/kg) of the syringin which was validated by the alteration in the immunoglobulin E (IgE) levels, cytokines levels, histopathological evaluation inflammatory cell count, lung weight, nitrite (NO) levels, oxidative stress biomarkers and gene markers. The treatment of syringin intensely reduced the increased IgE, inflammatory cytokines, WBC count and restored the antioxidant stress markers OVA stimulated animals. In addition, a significant reduction in inflammation and mucus production was evidenced in histopathological analysis which was further validated by suppression NF-κB pathway activation by syringin. These results suggest that syringin may improve asthma symptoms in OVA-induced mice by modulating NF-κB pathway activation.

中文翻译：

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丁香苷通过 NF-κB 信号通路减轻 BALB/c 小鼠哮喘模型中卵清蛋白诱导的肺部炎症

哮喘是一种肺气道的过敏性慢性炎症性疾病，其特征是白细胞浸润和炎性细胞因子的释放与其发病机制相关的复杂途径。从各种药用植物中提取的丁香苷已被广泛用于治疗炎症性疾病。因此，本研究旨在进一步探讨丁香素对卵清蛋白 (OVA) 诱发哮喘小鼠模型的保护作用。OVA 致敏的 BALB 小鼠用三种剂量（25、50 和 100 毫克/千克）的丁香苷进行腹膜内治疗，这通过免疫球蛋白 E (IgE) 水平、细胞因子水平、组织病理学评估炎症细胞计数、肺重量的改变来验证、亚硝酸盐 (NO) 水平、氧化应激生物标志物和基因标志物。丁香苷的治疗强烈降低了增加的 IgE、炎性细胞因子、WBC 计数并恢复了 OVA 刺激的动物的抗氧化应激标志物。此外，组织病理学分析证实了炎症和粘液产生的显着减少，这进一步通过丁香素抑制 NF-κB 通路激活得到证实。这些结果表明，丁香苷可能通过调节 NF-κB 通路激活来改善 OVA 诱导小鼠的哮喘症状。