The comparison of fitness between cells leads to the elimination of less competent cells in the presence of more competent neighbors via cell competition (CC). This phenomenon has been linked with several cancer-related genes and thus may play an important role in cancer. Various processes are involved in the regulation of tumor initiation and growth, including tumor hypoxia, clonal stem cell selection, and immune cell response, all of which have been recently shown to have a potential connection with the mechanisms involved in CC. This review aims to unravel the relation between these processes and competitive cell interactions and how this affects disease progression.

细胞之间适应性的比较导致在通过细胞竞争 (CC) 存在更有能力的邻居的情况下消除能力较低的细胞。这种现象与几个癌症相关基因有关，因此可能在癌症中发挥重要作用。各种过程都涉及肿瘤发生和生长的调节，包括肿瘤缺氧、克隆干细胞选择和免疫细胞反应，所有这些最近都被证明与 CC 所涉及的机制有潜在联系。本综述旨在阐明这些过程与竞争性细胞相互作用之间的关系，以及这如何影响疾病进展。