Supramolecular macrocyclic compounds including cyclodextrin, pillararene, calixarene, and cucurbituril are a family of multifarious hosts capable of selectively binding with guests via their intrinsic cavities. They have been used as ideal functional entities on the surface of inorganic nanoparticles to improve their solubility, stability, and biocompatibility in vivo. Macrocyclic compounds can be attached onto the surface of inorganic nanoparticles via covalent or noncovalent bonds, thus acting as a versatile anchoring point, which allows reversible complexation with small molecules via host-guest recognitions. A variety of functional tags including imaging probes, targeting groups, and therapeutic agents can be introduced for further functionalization of the organic-inorganic hybrid nanoparticles. The macrocycles-based organic-inorganic nanohybrids have shown remarkable properties and significant potential in various biomedical applications thanks to the surface modification of macrocycles. Here, we review the versatile construction of macrocycles-based hybrid nanomaterial platforms and discuss their significant potential in biomedical and related applications.

超分子大环化合物包括环糊精，斯达拉林，杯芳烃和葫芦科酯，是一类各种各样的宿主，能够通过它们的固有腔与客体选择性结合。它们已被用作无机纳米颗粒表面上的理想功能实体，以改善其在体内的溶解度，稳定性和生物相容性。大环化合物可以通过共价键或非共价键连接到无机纳米颗粒的表面，从而充当通用的固定点，从而可以通过客体识别来与小分子可逆地络合。可以引入各种功能标签，包括成像探针，靶向基团和治疗剂，以进一步使有机-无机杂化纳米颗粒功能化。由于大环化合物的表面改性，基于大环化合物的有机-无机纳米杂化物在各种生物医学应用中显示出了卓越的性能和巨大的潜力。在这里，我们回顾了基于大环化合物的杂化纳米材料平台的多功能构建，并讨论了它们在生物医学和相关应用中的巨大潜力。