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Macrophage-mediated cancer drug delivery
Materials Today Sustainability ( IF 7.8 ) Pub Date : 2020-11-04 , DOI: 10.1016/j.mtsust.2020.100055
H.-F. Wang , Y. Liu , G. Yang , C.-X. Zhao

Cell-mediated drug delivery systems have attracted significant research interest in the past years due to their superior properties such as excellent biocompatibility, potential long circulation, intrinsic homing properties, ability to permeate biological barriers. Macrophages, as one major phagocytes of the innate immune system, represent a promising target for cancer drug delivery because, on one hand, they play critical roles in tumor microenvironment in various stages of tumor progression, and on the other hand, they can be harnessed as Trojan horses for enhanced drug delivery. This article provides a mini-review of the different aspects of macrophages for cancer therapy including tumor-associated macrophages (TAMs) in tumor microenvironment, novel cancer treatment targeting TAMs, and nanoparticle-loaded macrophages as tumor-infiltrating drug carriers.



中文翻译:

巨噬细胞介导的癌症药物递送

细胞介导的药物递送系统由于其优越的性能,例如出色的生物相容性,潜在的长循环,固有的归巢特性,渗透生物屏障的能力,在过去几年中引起了广泛的研究兴趣。巨噬细胞作为先天免疫系统的主要吞噬细胞,代表着一种有希望的抗癌药物靶标,因为一方面,巨噬细胞在肿瘤进展的各个阶段均在肿瘤微环境中发挥关键作用,另一方面,它们也可以被利用。作为特洛伊木马来增强药物输送。本文简要介绍了巨噬细胞用于癌症治疗的各个方面,包括肿瘤微环境中的肿瘤相关巨噬细胞(TAM),针对TAM的新型癌症治疗,

更新日期:2020-11-04
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