The concern about pharmaceuticals has been increased over the last decade due to their burgeoning consumption. Ibuprofen has an extensive presence in surface water with risks for the aquatic biota. This study focuses on the effects of ibuprofen at environmental concentrations on the survival, transcriptional level, and enzymatic activity for 24, 96 h on Chironomus riparius. Ibuprofen developed a substantial effect on survival by all the conditions. mRNA levels of EcR, Dronc, and Met (endocrine system), hsp70, hsp24, and hsp27 (stress response), and Proph and Def (immune system) were modified, joined to increased GST and PO activity. The results confirmed alterations on the development of C. riparius, as well as two essential mechanisms, involved in protection against external toxicological challenge. Ibuprofen poses an incipient risk to C. riparius and could at an organismal level by compromising their survival, development, and ability to respond to adverse conditions on the future populations.

在过去的十年中，由于药物的迅速发展，人们对药物的关注日益增加。布洛芬广泛存在于地表水中，存在水生生物群的风险。这项研究的重点是布洛芬在环境浓度下对河豚草（Chironomus riparius）的存活，转录水平和24小时，96小时的酶活性的影响。布洛芬在所有条件下均对存活率产生了实质性影响。的mRNA水平的EcR，Dronc，和蛋氨酸（内分泌系统），HSP70，hsp24，和HSP27（应激反应），和Proph和防守（免疫系统）被修改，以增加GST和PO活性。该结果证实了对河岸线虫的发育的改变，以及参与抵抗外部毒理学挑战的两个基本机制。布洛芬对瑞氏梭菌有初期风险，并且可能通过损害其生存，发育和对未来人群对不利条件的反应能力而在机体水平上出现。