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Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication
Genes & Genomics ( IF 2.1 ) Pub Date : 2020-11-03 , DOI: 10.1007/s13258-020-01014-7
Yong-Moon Lee , Man Hwan Oh , Jai-Hyang Go , Kyudong Han , Song-Yi Choi

Background

Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types.

Conclusion

Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.



中文翻译:

三阴性乳腺癌的分子亚型:亚型类别的理解及其临床意义

背景

三阴性乳腺癌(TNBC)是一个异质实体,包含具有不同分子特征的几种亚型。TNBCs患者对化学疗法表现出不可预测的反应,并且进一步缺乏有效的药物。因此,正在进行许多研究以发现适合于在每种分子亚型中具有特定遗传改变的患者的靶向治疗。根据基因表达模式,TNBCs被分为四种主要的分子亚型。这些是管腔雄激素受体(LAR),间充质样,免疫调节(IM)和基底样类型。

结论

在这里,我们讨论每种亚型的独特分子特征以及抗癌治疗的有希望的靶标。

更新日期:2020-11-04
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